Abstract Background and objective: This study was conducted to evaluate the clinical efficacy of laser hair removal using a novel 650-microsecond pulsed Nd:YAG 1064 nm laser. Materials and Methods: Patients seeking laser hair removal with no prior laser hair removal treatment in the past one year were recruited from a dermatology clinic. A total of 298 adult subjects with skin types II-IV, received an average of 6 treatments at four-week intervals in various body locations including the facial, axillary, back, neck, arms, legs and bikini areas. At each four-week follow up and at six months post final treatment, an analysis of the clinical improvement as defined by percent hair reduction was performed.